Coronary CT Angiography in Acute Chest Pain is a Cost Effective Risk Stratification Strategy

Completed · Phase 3

Conditions studied: Acute Chest Pain

In brief

This study will evaluate the impact of adding coronary computed tomographic angiography (CTA) on health care costs for diagnosing patients with acute chest pain.

Key facts

Study ID

NCT00825435

Run by

University of Texas Southwestern Medical Center

People needed

60

Starts

2008-10-01

Expected to finish

2012-09-01

Last updated by the study team

2019-09-17

Who can join

Age: 35 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• patients who complain of typical or atypical chest pain (that is compatible with ischemia during the past 12 hrs);
• patients a prediction of low to intermediate risk of myocardial infarction and/or complications according to established criteria;
• patients who have normal or non-diagnostic electrocardiograms;
• patients who have negative cardiac biomarker including creatine kinase-MB, myoglobin, and/or cardiac troponin I at initial testing; patients who require admission to the hospital by the EP at the time of risk-stratification;
• patients who require cardiology consultation in the ED 7. patients who are age 35 years or older;
• patients who are able to hold their breath for ≥ 15 seconds (to obtain a quality static anatomical image, scanning requires at least fifteen seconds of breath holding;
• patients who have heart rate of < 70 beats per minute before or after the administration of beta-blocker medication

You may not qualify if…

• patients who have a contraindication to iodinated and/ or beta-blocking drugs; patients who have compromised renal function defined as creatinine ≥ 1.2 mg/dl;
• patients who are pregnant, suspected pregnant or other vulnerable populations e.g., incarcerated patients;
• patients who have documented CAD by prior invasive coronary angiography or coronary CT angiography and/or patients with coronary artery stents, prior angioplasty, or prior coronary artery bypass grafts (CABG);
• patients who have had prior cardiac imaging (within the past year) with normal result including invasive coronary angiography, coronary CT angiography, or nuclear stress testing;
• patients who are unstable; patients who have an electrocardiogram diagnostic of ischemia or myocardial infarction (significant Q waves, ST -segment deviations > 0.5 mm, or T wave inversions);
• patients in atrial fibrillation or have markedly irregular rhythm 9. patients who have had contrast administration within the past 24hrs;
• patients without an 18 gauge antecubital intravenous access; patients who have a medical home outside of the UTSWMC/Parkland Medical system.

Where it is running

• Parkland Hospital — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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