Detection and Classification of Colon Polyps

Completed · Phase 2

Conditions studied: Colon Polyps

In brief

Colon cancer is the third most common cancer in western society. To prevent colon cancer it is recommended for people to undergo a screening colonoscopy at the age of fifty. The purpose of the colonoscopy is to remove polyps, since some of these lesions are precancerous. Precancerous polyps are called adenomas. This method of prevention is effective, but the standard colonoscopy currently used does not detect all polyps. Studies have reported a polyp miss rate of about 24%. Furthermore, we are unable to distinguish precancerous polyps from benign polyps, also known as hyperplastic polyps, with standard colonoscopy. This results in all polyps being removed at time of colonoscopy, even the benign polyps. To help improve the detection of colon polyps new endoscopic technologies have been developed. These technologies include high definition white light (HDWL)and high definition narrow band imaging (HDNBI). HDWL improves the overall resolution of the images seen during colonoscopy. HDNBI can help us better classify polyps by enhancing their tissue appearance as well as seeing small blood vessels and capillaries. The goal of this study to determine if HDNBI imaging shows an increased polyp detection rate when compared to the current standard colonoscopy. In addition to develop a classification system to help better differentiate between precancerous polyps and their benign counterparts using HDWL and HDNBI.

Key facts

Study ID

NCT00825292

Run by

Mayo Clinic

People needed

110

Starts

2006-07-01

Expected to finish

2008-12-01

Last updated by the study team

2009-01-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 years or older.
• Informed written consent

You may not qualify if…

• History of inflammatory bowel disease.
• Patients with severe cardiopulmonary disease precluding colonoscopy.
• Presence of conditions not allowing for polypectomy or biopsy (e.g. coagulation disorder).
• Known familial polyposis syndrome (FAP, HNPCC, Juvenile polyposis, etc)
• Sub-optimal preparation for the procedure, which will be determined by patient history or based on the initial colonoscopy.
• Pregnancy

Where it is running

• Mayo Clinic — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.