Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)

Completed · Not applicable

Conditions studied: Glaucoma

In brief

We have completed a study in which we examined the response of the retinal circulation to changes in posture from sitting to lying down in patients with primary open angle glaucoma (POAG). This alteration in position produces changes in the local blood pressure at the entrance to the retinal vasculature. In a healthy retina, the vasculature adapts by dilating and constricting in order to maintain a steady blood flow rate. In an eye with POAG, this often does not occur. As a result, there are large fluctuations in blood flow which may produce the retinal neuronal damage associated with glaucoma. The purpose of this study is to demonstrate that topical anti-glaucoma treatments with agents that have vasoactive as well as IOP-lowering effects can have a beneficial effect on maintaining a steady retinal blood flow rate even when there are changes in local blood pressure.

Key facts

Study ID

NCT00824824

Run by

Massachusetts Eye and Ear Infirmary

People needed

21

Starts

2009-01-01

Expected to finish

2012-08-01

Last updated by the study team

2017-04-04

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• POAG
• Age 40 to 80 years
• Untreated IOP greater than 21 mm Hg

You may not qualify if…

• More than two IOP lowering medications
• Exfoliation or pigment dispersion syndrome
• Diabetic retinopathy
• History of ocular surgery

Where it is running

• Massachusetts Eye and Ear Infirmary — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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