Phenytoin and Multidose Activated Charcoal

Completed · Not applicable

Conditions studied: Phenytoin Toxicity

In brief

Phenytoin is a medicine used to treat seizures. If too much is taken, patients have ill effects including sleepiness, unsteady gait, and eye problems. The amount of drug in their system can be measured in their blood. Charcoal is a medicine that can absorb phenytoin. We want to see if giving multiple doses of charcoal will quicken the removal of phenytoin from the blood. This is theorized to occur as charcoal absorbs phenytoin from across the intestines and then is secreted in the stool. Patients will be selected to receive either charcoal in multiple doses or no charcoal and their serum levels will be drawn repeatedly to follow their level. The different groups will then be compared to see if multidose charcoal does indeed increase the elimination of phenytoin from the body.

Key facts

Study ID

NCT00823264

Run by

Emory University

People needed

17

Starts

2008-08-01

Expected to finish

2012-01-01

Last updated by the study team

2014-09-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Phenytoin level > 30 mg/L

You may not qualify if…

• Age < 18
• Known allergy to Activated Charcoal
• Pregnant
• Inability to take PO drugs
• Non English speaking
• Inability to give consent
• Any prisoners

Where it is running

• Grady Memorial Hospital — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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