Pain Catastrophizing as a Cause for Systemic Inflammation

Completed · Phase 1

Conditions studied: Musculoskeletal Pain

In brief

Research shows that the immune system is involved in chronic pain. The immune system is involved in the process of inflammation. The investigators are still learning about the factors that cause inflammation, but know it can be measured in the blood. The purpose of this study is to understand how negative thoughts affect the immune system in women with chronic pain. A sub-study asks subjects to store a blood sample for future research by the PI aimed at identifying genetic markers in women with chronic pain.

Key facts

Study ID

NCT00823147

Run by

Beth Darnall, PhD

People needed

93

Starts

2009-01-01

Expected to finish

2014-09-01

Last updated by the study team

2019-08-06

Who can join

Age: 18 and older, up to 70. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women between the ages 18-70
• Non-smokers
• Diagnosed with musculoskeletal chronic pain
• Normal menstrual cycle or postmenopausal

You may not qualify if…

• Psychosis or suicidality
• Current Major Depression
• Former intravenous drug user
• Needle/blood/injection phobia
• Limited venous access
• Sex-steroid dysregulation
• Self-Reported Pregnancy
• Fibromyalgia or inflammatory disease, e.g. lupus
• Active corticosteroid regimen
• Taking beta blockers
• Taking oral contraception or hormone therapy

Where it is running

• Oregon Health and Science Universtiy — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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