Subcutaneous Botulinum Toxin for Cutaneous Allodynia - Enriched Responder Trial
Stopped early · Not applicable · Has a placebo group
Conditions studied: Pain
In brief
Superficial injection of Botulinum toxin has been advocated for cosmetic purposes but has also been reported to be helpful for some pain conditions. The investigators have observed prolonged profound analgesia following subcutaneous superficial injection of Botulinum Toxin Type A (BTA) in patients with certain types of neuropathic pain. the investigators propose to study if addition of BTA extends pain relief compared to placebo when injected subcutaneously into areas of cutaneous allodynia (the property that a normally non-noxious stimulus is perceived as painful).
Key facts
- Study ID
- NCT00822926
- Run by
- Stanford University
- People needed
- 5
- Starts
- 2009-01-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2017-08-15
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Moderate to severe pain (greater than 2/10) of duration more than 6 months despite previous therapy, excluding botox injection
- The patient exhibits at least 80% pain relief following injection of local anesthetic subcutaneously into scar as assessed by change in NRS
- Patient reports more than 3 weeks of greater than 50% pain relief from previous botox injection
- The patient reports the presence of hyperalgesia, allodynia, dysesthesia, or hypoesthesia surrounding the scar in the absence of the botox injection
- Age 18-100
- Ability to read, write, and converse in English, provide informed consent, and follow study procedures
You may not qualify if…
- Any neuromuscular disorder such as myasthenia gravis, eaton lambert, muscular dystrophy
- Any ongoing legal action related to their pain
- Allergy to local anesthetics
- Any ongoing disability claim
- Currently being treated for any severe psychiatric disorder, including anxiety or depression
- History of any adverse reaction to botulinum toxin
- History of botulism
- Untreated infection
- Coagulopathy
- (Females) - positive pregnancy test
- Surgery in the last 6 months
Where it is running
- Stanford University School of Medicine — Stanford, California, United States
Full record on ClinicalTrials.gov
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