A Translational Approach to Gitelman Syndrome

Completed · Not applicable

Conditions studied: Gitelman Syndrome

In brief

This study will test the response to a single dose of thiazide diuretic as a diagnostic test for Gitelman syndrome. Individuals with hypokalemic alkalosis will be enrolled. After a baseline study, they will have the response to 50 mg hydrochlorothiazide on fractional chloride excretion examined.

Key facts

Study ID

NCT00822107

Run by

Oregon Health and Science University

People needed

8

Starts

2009-01-01

Expected to finish

2013-09-01

Last updated by the study team

2019-04-05

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Institutional Review Board (IRB) approved written Informed Consent and Health Insurance Portability and Accountability Act (HIPAA) Authorization as per national regulations, must be obtained from the subject or legally authorized representative prior to any study-related procedures (including withdrawal of prohibited medication, if applicable).
• Subject is between the ages of 21 and 60.
• Female subjects of child bearing potential must have a negative urine pregnancy test at the screening visit (Study Visit 1) and must agree to maintain effective birth control during the study.
• Subjects who are referred to Dr. Ellison for evaluation of normotensive hypokalemia of unknown etiology

You may not qualify if…

• Subject has known allergy to thiazide or sulfonamide medications
• Subject is pregnant or lactating.
• Subject has major systemic illnesses that affect potassium regulation through pathology or pharmacologic treatment. This category includes:
• Hypertension
• Requiring regular pharmacological control
• History of blood pressure greater than 140mmHg systolic and 90mmHg diastolic
• Congestive heart failure
• Cirrhosis of the liver
• Subject has documented kidney disease resulting in anuria, proteinuria or abnormal urinalysis, or requiring dialysis for treatment.

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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