Inflammation and the Host Response to Injury (In Healthy Volunteers)

Completed · Phase 1

Conditions studied: Immune System

In brief

The body's immune response to injury or infection is very complex.Endotoxin is a man-made substance, which causes the body to "mimic" sickness (fever,chills, and achiness)for a few hours. This study is designed to determine whether certain proteins, genetics, or heart rate variability change affects the body's response to endotoxin.

Key facts

Study ID

NCT00820989

Run by

Rutgers, The State University of New Jersey

People needed

116

Starts

2000-02-01

Expected to finish

2011-02-01

Last updated by the study team

2014-05-21

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Good general health as demonstrated by medical history,physical exam, and laboratory tests within 6 weeks of study.
• Written informed consent prior to the performance of any study related procedure.

You may not qualify if…

• History of cancer, rheumatoid arthritis, or immunological, renal, hepatic, endocrine, neurologic, heart disease or hypertension
• Recent history of alcohol or drug abuse
• Mental capacity limited to the extent that the subject cannot provide written informed consent or information regarding treatment-emergent adverse events and/or tolerance of study medication and/or study procedures
• Exposure to any experimental agent or procedure within 30 days of study
• Pregnancy or breast feeding
• Prior exposure to endotoxin in an experimental setting -

Where it is running

• Rutgers-RWJMS — New Brunswick, New Jersey, United States

Full record on ClinicalTrials.gov

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