Docetaxel, Carboplatin, Trastuzumab, and Lapatinib in Treating Patients With Early Stage Breast Cancer
Completed · Phase 2
Conditions studied: Breast Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as docetaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Lapatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving docetaxel together with carboplatin, trastuzumab, and lapatinib may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects of giving docetaxel together with carboplatin, trastuzumab, and lapatinib in treating patients with early stage breast cancer.
Key facts
- Study ID
- NCT00820872
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 30
- Starts
- 2009-02-01
- Expected to finish
- 2019-08-15
- Last updated by the study team
- 2019-10-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Front Range Cancer Specialists — Fort Collins, Colorado, United States
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Trinity Cancer Center at Trinity Medical Center - 7th Street Campus — Moline, Illinois, United States
- Study site — Moline, Illinois, United States
- St. Francis Hospital and Health Centers - Beech Grove Campus — Beech Grove, Indiana, United States
- Elkhart General Hospital — Elkhart, Indiana, United States
- Howard Community Hospital — Kokomo, Indiana, United States
- Center for Cancer Therapy at LaPorte Hospital and Health Services — La Porte, Indiana, United States
- Reid Hospital & Health Care Services — Richmond, Indiana, United States
- CCOP - Northern Indiana CR Consortium — South Bend, Indiana, United States
- Memorial Hospital of South Bend — South Bend, Indiana, United States
- Saint Joseph Regional Medical Center — South Bend, Indiana, United States
- South Bend Clinic — South Bend, Indiana, United States
- McFarland Clinic, PC — Ames, Iowa, United States
- Study site — Bettendorf, Iowa, United States
- Cedar Rapids Oncology Associates — Cedar Rapids, Iowa, United States
- Mercy Regional Cancer Center at Mercy Medical Center — Cedar Rapids, Iowa, United States
- Medical Oncology and Hematology Associates - West Des Moines — Clive, Iowa, United States
- CCOP - Iowa Oncology Research Association — Des Moines, Iowa, United States
- John Stoddard Cancer Center at Iowa Methodist Medical Center — Des Moines, Iowa, United States
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center — Des Moines, Iowa, United States
- Medical Oncology and Hematology Associates at Mercy Cancer Center — Des Moines, Iowa, United States
- Mercy Cancer Center at Mercy Medical Center - Des Moines — Des Moines, Iowa, United States
- John Stoddard Cancer Center at Iowa Lutheran Hospital — Des Moines, Iowa, United States
- Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
Full record on ClinicalTrials.gov
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