Efficacy of Post-operative Antibiotic Prophylaxis for Thoracic Surgery Requiring Tube Thoracostomy
Completed · Not applicable · Has a placebo group
Conditions studied: Antibiotic Prophylaxis
In brief
The purpose of this study is to evaluate if post-operative antibiotic prophylaxis decreases infectious complications when compared to pre-operative antibiotics alone, in patients undergoing elective thoracic surgery requiring tube thoracostomy (chest tube).
Key facts
- Study ID
- NCT00818766
- Run by
- Brigham and Women's Hospital
- People needed
- 251
- Starts
- 2008-03-01
- Expected to finish
- 2011-04-01
- Last updated by the study team
- 2017-04-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18 years or older undergoing elective thoracic surgery at Brigham \& Women's Hospital. The majority of these patients will be undergoing lung resection for either the evaluation of a lung mass, or for the removal of a known malignancy. Some participants may be undergoing biopsy or removal of a mediastinal mass.
- Undergoing thoracic surgery procedure expected to require tube thoracostomy.
- Ability to give informed consent
You may not qualify if…
- Patients undergoing the following complex thoracic surgical procedures:
- Pneumonectomy
- Decortication
- Chemical pleurodesis
- Pleurectomy
- Lung volume reduction
- Esophagectomy
- Patients with the following conditions:
- Prior diagnosis of empyema or lung abscess.
- Cystic fibrosis
- Known or suspected pneumonia pre-operatively.
- Known hypersensitivity to beta-lactam antibiotics and vancomycin
- Current or recent antibiotic use within one week of surgery.
- Anticipated requirement for postoperative antibiotic in addition to 48 hours of cefazolin or vancomycin.
- Renal insufficiency with estimated creatinine clearance <60 ml/minute.
Where it is running
- Brigham & Women's Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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