The Impact of Grapefruit Juice on the Response to Clopidogrel

Completed · Phase 4

Conditions studied: Healthy

In brief

This study will measure the percentage of platelet aggregation inhibition with a loading dose of clopidogrel (300 mg) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz of grapefruit juice. It will also measure the percentage of platelet aggregation inhibition with a maintenance dose of clopidogrel (75 mg/day) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz grapefruit juice daily.

Key facts

Study ID

NCT00817999

Run by

Creighton University

People needed

32

Starts

2008-11-01

Expected to finish

2011-07-01

Last updated by the study team

2012-10-01

Who can join

Age: 19 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 19-40
• Health status confirmed by medical history and physical examination and laboratory analysis

You may not qualify if…

• Pregnancy
• Taking routine prescription or over-the-counter prescriptions
• Taken over-the-counter analgesic/anti-inflammatory medication within two weeks of study participation
• Recently had grapefruit juice or regularly drinks grapefruit juice

Where it is running

• Creighton Cardiac Center — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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