A Study to Evaluate the Effects of LCI699 on Cortisol in Participants With Hypertension
Completed · Phase 2 · Has a placebo group
Conditions studied: Hypertension
In brief
This study determined the maximum dose of LCI6999 with respect to effect on the ACTH-stimulated cortisol response in participants with hypertension.
Key facts
- Study ID
- NCT00817414
- Run by
- Novartis
- People needed
- 63
- Starts
- 2009-01-14
- Expected to finish
- 2009-08-12
- Last updated by the study team
- 2021-06-02
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of hypertension with blood pressure ≥ 140/90 millimeters of mercury (mmHg) and < 180/110 mmHg on current antihypertensive treatment
- Male and female participants 18-75 years of age
- Participants must weigh at least 50 kilograms (kg)
You may not qualify if…
- Recent history of myocardial infarction, heart failure, unstable angina, coronary artery bypass graft, percutaneous coronary intervention, hypertensive encephalopathy, cerebral accident or transient ischemic attack
- Clinically significant electrocardiography (ECG) findings related to cardiac conduction defects
- Type 1 diabetes or uncontrolled type 2 diabetes (haemoglobin A1c [HbA1c] > 9%)
- Malignancies within the last 5 years (excluding basal cell skin cancer)
- Liver disease
- Other protocol-defined inclusion/exclusion criteria may apply.
Where it is running
- Impact Clinical Trials — Beverly Hills, California, United States
- Associated Pharmaceutical Research Center, Inc — Buena Park, California, United States
- Innovative Clinical Research, Inc — Harbor City, California, United States
- Long Beach Center for Clinical Research — Long Beach, California, United States
- Metro Clinical Research — Littleton, Colorado, United States
- Clinical Study Center of Asheville, LLC — Asheville, North Carolina, United States
- Northstate Clinical Research — Lenoir, North Carolina, United States
- Tipton Medical & Diagnostic Center — Tipton, Pennsylvania, United States
- Punzi Medical Center — Carrollton, Texas, United States
- dgd Research, Inc — San Antonio, Texas, United States
- Encode Clinic — Reykjavik, SA, Iceland
Full record on ClinicalTrials.gov
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