Validation of Stenosis Assessment by Coronary Artery Computed Tomography Against Invasive Measurements of Fractional Flow Reserve in Patients With Significant Coronary Artery Stenoses

Completed · Not applicable

Conditions studied: Coronary Artery Stenosis

In brief

This study will evaluate the effectiveness of CorCTA by comparing the results of the test with another imaging method called Fractional Flow Reserve (FFR), which is done as a part of the cardiac catheterization.

Key facts

Study ID

NCT00817102

Run by

Piedmont Healthcare

People needed

25

Starts

2008-11-01

Expected to finish

2013-04-01

Last updated by the study team

2014-04-15

Who can join

Age: 21 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 21-85
• Presence of at least one obstructive coronary artery stenosis as defined by:
• Previous catheterization or CT angiogram with any lesion 70% or greater
• Previous positive functional stress test (this does not include CTA alone)
• Ability and Willingness to provide informed consent
• Ability and Willingness to perform required follow up procedures

You may not qualify if…

• History of coronary artery bypass graft surgery
• Previously revascularized lesion
• Creatinine>1.6 mg/dL or GFR<30 pre-procedure per institutional standards
• Known Pregnancy
• Inability to perform CTA
• Arrhythmia precluding diagnostic CT examination
• Contrast agent allergy that cannot be adequately premedicated
• Severe PVD precluding cardiac catheterization
• Patient not a candidate for IVUS and FFR
• Inability or unwillingness to provide informed consent
• Inability or unwillingness to perform required follow up procedures

Where it is running

• Piedmont Hospital — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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