Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?

Completed · Not applicable · Has a placebo group

Conditions studied: Airway Inflammation

In brief

The purpose of this study is to examine biological pathways of altered blood vessel function resulting from breathing airborne particulate. Blood artery function in healthy men will be measured after particulate exposure either on placebo or on an asthma medication that stops production of an inflammatory biological agent. Lung and blood profiles will be obtained before and after exposure to exhaust fumes. We believe that the inflammatory agent produced by the lungs from breathing these particles causes abnormal artery function.

Key facts

Study ID

NCT00814281

Run by

Marywood University

People needed

24

Starts

2007-05-01

Expected to finish

2009-05-01

Last updated by the study team

2009-05-21

Who can join

Age: 18 and older, up to 30. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy male subjects
• between 18 and 30 years of age
• participant in endurance sport

You may not qualify if…

• history of blood clotting
• history of coagulation problems
• History of spontaneous pneumothorax

Where it is running

• Marywood University — Scranton, Pennsylvania, United States

Full record on ClinicalTrials.gov

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