Neurotrophic Factors and Depression
Completed · Phase 4 · Has a placebo group
Conditions studied: Depression
In brief
Study intended to determine if there are baseline differences in serum neurosteroid levels and neurotrophic factor (BDNF) levels in healthy controls vs unmedicated depressed subjects, and whether the levels of these change with antidepressant treatment. Study also intended to determine if baseline neurosteroid/ BDNF levels, and the change in these levels with =treatment, are correlated with clinical antidepressant response to escitalopram (Lexapro).
Key facts
- Study ID
- NCT00812994
- Run by
- University of California, San Francisco
- People needed
- 30
- Starts
- 2003-01-01
- Expected to finish
- 2008-11-01
- Last updated by the study team
- 2008-12-22
Who can join
Age: 22 and older, up to 55. Sex: male. Healthy volunteers: accepted.
You may not qualify if…
- Individuals with co-morbid panic disorder were excluded, since they may poorly tolerate typical starting doses of antidepressants , and individuals with co-morbid post-traumatic stress disorder were excluded, since they may have neuroendocrine regulatory responses different from those of depressed subjects without PTSD. Exclusion criteria for both groups included recent (within 6 months) alcohol or drug abuse as defined by DSM-IV criteria, concurrent psychotherapeutic interventions, poor medical health or abnormal clinical labs, active suicidality, and use of medications that could interfere with the study.
Where it is running
- University of California San Francisco — San Francisco, California, United States
- UCSF — San Francisco, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.