A Study of R1507 in Combination With Multiple Standard Chemotherapy Treatments in Patients With Advanced Solid Tumors

Stopped early · Phase 1

Conditions studied: Neoplasms

In brief

This study will evaluate the safety and tolerability of R1507 in combination with 12 distinct standard chemotherapy drug regimens and an additional R1507 monotherapy arm in patients with advanced malignant neoplasms.The 12 regimens will be tested in parallel. There are 3 subsets of patients who are eligible for the study: untreated, treated and requiring further treatment, or treated and failed and for whom adding R1507 represents a suitable treatment for their disease. All regimens will first test doses of R1507 which are less than the maximally administered dose, and if tolerated, the dose will be escalated in subsequent patients. The anticipated time on study treatment is until disease progression, and the target sample size is 100-500 individuals.

Key facts

Study ID

NCT00811993

Run by

Hoffmann-La Roche

People needed

104

Starts

2009-02-01

Expected to finish

2012-12-01

Last updated by the study team

2016-11-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adult patients, >=18 years of age;
• malignant neoplasms;
• failed prior standard curative therapy;
• ECOG performance Status of 0 or 1;
• adequate bone marrow, hepatic and renal function;
• life expectancy greater than 8 weeks.

You may not qualify if…

• chemotherapy within 2 weeks of start of therapy;
• prior irradiation within 4 weeks prior to start of therapy;
• prior treatment with agents targeting IGF-IR inhibition, or other investigational agents;
• major surgery or significant traumatic injury within 2 weeks prior to study start;
• patients receiving concurrent antibody or immunotherapy;
• other exclusion criteria are related to specific treatment regimens.

Where it is running

• Study site — Tucson, Arizona, United States
• Study site — San Francisco, California, United States
• Study site — Santa Monica, California, United States
• Study site — Washington D.C., District of Columbia, United States
• Study site — Chicago, Illinois, United States
• Study site — Rochester, Minnesota, United States
• Study site — Chapel Hill, North Carolina, United States
• Study site — Houston, Texas, United States

Full record on ClinicalTrials.gov

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