Trial Comparing the Optimal Timing of Antibiotic Prophylaxis at the Time of Cesarean Delivery

Completed · Phase 3

Conditions studied: Cesarean Section, Infection

In brief

The purpose of this study is to evaluate the rates of maternal and neonatal infectious morbidity in gravid patients undergoing cesarean delivery. Specifically, the investigators are examining whether the timing of antibiotic administration has any effect on rates of maternal and neonatal infections, neonatal sepsis work-up and length of hospital stay.

Key facts

Study ID

NCT00811603

Run by

MemorialCare

People needed

50

Starts

2008-08-01

Expected to finish

2009-09-01

Last updated by the study team

2009-09-18

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Patients 18 years of age or older
• Any patient at term (>37 weeks gestation) undergoing a scheduled cesarean delivery

You may not qualify if…

• Women younger than 18 years
• Patients who are febrile during or prior to screening or with a diagnosis of clinical suspicion of endometritis (with or without maternal fever)
• Patients who present with ruptured membranes
• Known fetal malformations
• Contraindications to cefazolin administration (known anaphylactic reaction to penicillins or known cephalosporin allergy)
• Any exposure to antibiotics in one week prior to cesarean delivery
• Obstetrical indication for an emergent cesarean delivery
• Patients taking glucocorticoids or other immunosuppressant therapy

Where it is running

• Long Beach Memorial Medical Center — Long Beach, California, United States
• University of California, Irvine Medical Center — Orange, California, United States

Full record on ClinicalTrials.gov

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