Zinc for the Treatment of Herpes Simplex Labialis (HSL)

Completed · Phase 3 · Has a placebo group

Conditions studied: Herpes Simplex Labialis

In brief

Evaluate the effectiveness of a topical preparation of zinc to treat cold sores.

Key facts

Study ID

NCT00809809

Run by

Integrative Medicine Institute

People needed

157

Starts

2008-12-01

Expected to finish

2010-12-01

Last updated by the study team

2014-01-08

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with a history of HSL with at least 2 episodes/year for the past two years that have proceeded beyond the prodromal (initial) stage
• Male or female subjects between 18 and 65 years of age
• Symptoms or signs of HSL for less than one day (max. 36 hours from onset of symptoms to first visit)
• Confirmation of HSL by a clinician at the study site
• Willing to comply with study instructions and sign an informed consent

You may not qualify if…

• HSL symptoms or signs for more than one day
• Cold sore outbreak within the past 2 weeks
• Previous participation in this clinical trial
• Topical or oral antiviral drug use in the past 1 week
• Immune deficiency (HIV positive), chronic steroid therapy, present anti-neoplastic or radiation therapy, Hodgkin's disease, splenectomy, leukemia, myeloma, lymphoma, or another condition/drug per judgment of attending health care professional) or currently taking immune suppressive drugs. Previous organ or bone marrow transplant.
• Pregnancy or lactation
• Unable to travel to the clinic area for the required visits
• Apparent inability to understand or follow the instructions associated with the clinical study
• History of adverse events to the study material or facial cosmetics

Where it is running

• Steven Messer ND, DHANP — Tempe, Arizona, United States
• Deborah Thompson, MD MSPH — Santa Fe, New Mexico, United States
• Benjamin Kligler, MD — New York, New York, United States

Full record on ClinicalTrials.gov

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