Scripps Genomics Health Initiative

Running, not enrolling

Conditions studied: Genes

In brief

The specific aims for this project are to enroll up to 10,000 subjects who will have their genomes surveyed using the Navigenics™ Health Compass technology. The Navigenics Health Compass helps you understand what your genetic variants have to say about the future of your health, and gives you action steps to take control of your health today. In addition, the investigators will assess how the Navigenics Health Compass, results affect lifestyle decisions. The phenotyping information that can be analyzed with the resulting Navigenics genotype information will assist in identifying genetic variations associated with other traits and diseases. The uses of molecular markers such as cholesterol and glucose levels to assess disease risk are well established in clinical medicine today. Although these tools are useful in screening for subclinical disease, their predictive value is limited. Until recently, these molecular markers were the best risk assessment and screening tools in existence. Since the completion of the Human Genome Project, the era of personalized medicine, which exploits knowledge of the genes an individual carries that may predispose him/her to disease, has come to the forefront of research. The Navigenics Health Compass technology assesses risk for about over 20 common diseases and provides subjects with more accurate assessments of their individual predictive risk for developing these conditions than traditional biomarkers such as cholesterol and glucose levels. This may positively influence changes in lifestyle, as well as decisions to seek further medical evaluation associated with preventive strategies.

Key facts

Study ID

NCT00808587

Run by

Scripps Translational Science Institute

People needed

10000

Starts

2008-10-01

Expected to finish

2029-03-01

Last updated by the study team

2025-01-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 or older
• Able to read, write, and fluently understand English.
• Be reliable, cooperative, and willing to comply with all protocol specified procedures.
• Be able to understand and grant informed consent.
• Be able to provide payment for services rendered.
• Have an email address.

You may not qualify if…

• Intake of anything orally, i.e., food, beverage, cigarettes, brushing of teeth, 30 minutes prior to providing saliva sample.

Where it is running

• Scripps Health — San Diego, California, United States

Full record on ClinicalTrials.gov

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