Lume Lung 2 : BIBF 1120 Plus Pemetrexed Compared to Placebo Plus Pemetrexed in 2nd Line Nonsquamous NSCLC

Completed · Phase 3 · Has a placebo group

Conditions studied: Carcinoma, Non-Small-Cell Lung

In brief

The trial will be performed to evaluate if BIBF 1120 in combination with standard pemetrexed therapy is more effective than placebo (inactive capsule) plus standard pemetrexed therapy in patients with stage IIIB, IV or recurrent NSCLC. Safety information about BIBF1120/pemetrexed will be obtained.

Key facts

Study ID

NCT00806819

Run by

Boehringer Ingelheim

People needed

718

Starts

2008-12-01

Expected to finish

2015-12-01

Last updated by the study team

2017-02-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female patient aged 18 years or older.
• Histologically or cytologically confirmed Stage IIIB, IV (according to AJCC) or recurrent non small cell lung cancer (NSCLC) (non squamous histologies)
• Relapse or failure of one first line chemotherapy (in the case of recurrent disease one additional prior regimen is allowed for adjuvant, neoadjuvant or neoadjuvant plus adjuvant therapy).
• At least one target tumor lesion that has not been irradiated within the past three months and that can accurately be measured by magnetic resonance imaging (MRI) or computed tomography (CT) in at least one dimension (longest diameter to be recorded) as greater than or equal to 20 mm with conventional techniques or as greater than or equal to 10 mm with spiral CT.
• Life expectancy of at least three months.
• Eastern Cooperative Oncology Group (ECOG) score of 0 or 1.
• Patient has given written informed consent which must be consistent with the International Conference on Harmonization, Good Clinical Practice (ICH-GCP) and local legislation.

You may not qualify if…

• Previous therapy with other vascular endothelial growth factor (VEGF) inhibitors (other than bevacizumab) or pemetrexed for treatment of NSCLC
• Treatment with other investigational drugs or treatment in another clinical trial within the past four weeks before start of therapy or concomitantly with this trial
• Chemotherapy, hormone therapy, immunotherapy with monoclonal antibodies, treatment with tyrosine kinase inhibitors, or radiotherapy (except for treatment of extremities) within the past four weeks prior to treatment with the trial drug, i.e., the minimum time elapsed since the last anticancer therapy and the first administration of BIBF 1120 must be four weeks
• Inability to stop intake of NSAIDS (non steroidal anti inflammatory drugs) for several days
• Active brain metastases (e.g. stable for <4 weeks, no adequate previous treatment with radiotherapy, symptomatic, requiring treatment with anti-convulsants). Dexamethasone therapy will be allowed if administered as stable dose for at least one month before randomisation)
• Radiographic evidence of cavitary or necrotic tumors
• Centrally located tumors with radiographic evidence (CT or MRI) of local invasion of major blood vessels
• History of clinically significant haemoptysis within the past 3 months
• Therapeutic anticoagulation
• History of major thrombotic or clinically relevant major bleeding event in the past 6 months
• Significant cardiovascular diseases (i.e., hypertension not controlled by medical therapy, unstable angina, history of myocardial infarction within the past 6 months,
• Inadequate kidney, liver, blood clotting function
• Inadequate blood count
• Significant weight loss (> 10 %) within the past 6 weeks prior to treatment in the present trial
• Current peripheral neuropathy greater than or equal to Common Terminology Criteria for Adverse Events (CTCAE) Grade 2 except due to trauma
• Pre-existing ascites (abdominal fluid collection) and/or clinically significant pleural effusion ( fluid collection between the lung and chest wall)
• Major injuries and/or surgery within the past ten days prior to start of study drug
• Incomplete wound healing
• Active or chronic hepatitis C and/or B infection Additional exclusion criteria apply

Where it is running

• Boehringer Ingelheim Investigational Site — Fountain Valley, California, United States
• Boehringer Ingelheim Investigational Site — Fullerton, California, United States
• Boehringer Ingelheim Investigational Site — Long Beach, California, United States
• Boehringer Ingelheim Investigational Site — Meriden, Connecticut, United States
• Boehringer Ingelheim Investigational Site — Aventura, Florida, United States
• Boehringer Ingelheim Investigational Site — Boynton Beach, Florida, United States
• Boehringer Ingelheim Investigational Site — Jacksonville, Florida, United States
• Boehringer Ingelheim Investigational Site — Miami, Florida, United States
• Boehringer Ingelheim Investigational Site — New Port Richey, Florida, United States
• Boehringer Ingelheim Investigational Site — Port Saint Lucie, Florida, United States
• Boehringer Ingelheim Investigational Site — Stuart, Florida, United States
• Boehringer Ingelheim Investigational Site — Galesburg, Illinois, United States
• Boehringer Ingelheim Investigational Site — Skokie, Illinois, United States
• Boehringer Ingelheim Investigational Site — Indianapolis, Indiana, United States
• Boehringer Ingelheim Investigational Site — New Albany, Indiana, United States
• Boehringer Ingelheim Investigational Site — Witchita, Kansas, United States
• Boehringer Ingelheim Investigational Site — Ashland, Kentucky, United States
• Boehringer Ingelheim Investigational Site — Louisville, Kentucky, United States
• Boehringer Ingelheim Investigational Site — Burlington, Massachusetts, United States
• Boehringer Ingelheim Investigational Site — Springfield, Massachusetts, United States
• Boehringer Ingelheim Investigational Site — Saint Louis Park, Minnesota, United States
• Boehringer Ingelheim Investigational Site — Grand Island, Nebraska, United States
• Boehringer Ingelheim Investigational Site — Farmington, New Mexico, United States
• Boehringer Ingelheim Investigational Site — Dunkirk, New York, United States
• Boehringer Ingelheim Investigational Site — Downy, California, United States

Full record on ClinicalTrials.gov

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