Exercise-Induced Bronchospasm in Cystic Fibrosis

Completed

Conditions studied: Cystic Fibrosis, Bronchospasm

In brief

Exercise is an important clinical feature in cystic fibrosis. Better exercise capacity has been associated with better patient outcomes and quality of life. Exercise-induced bronchospasm is a condition, often associated with asthma, which may make exercise difficult. The role that exercise-induced bronchospasm has in people with cystic fibrosis is unknown. This study is designed to determine how often exercise-induced bronchospasm occurs in cystic fibrosis.

Key facts

Study ID

NCT00806455

Run by

Ohio State University

People needed

14

Starts

2008-07-01

Expected to finish

2013-08-01

Last updated by the study team

2013-11-19

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females with confirmed diagnosis of Cystic Fibrosis:
• 2 positive sweat chloride tests (or)
• genetic testing
• Age 12 years and older
• Baseline FEV1 ≥70% predicted
• Clinically stable over past 28 days:
• no change in chronic respiratory symptoms
• no need for antibiotics other then chronic maintenance therapies
• no need for oral steroids
• no increased use of bronchodilators
• Visit 1 FEV1 within 10% of baseline

You may not qualify if…

• History of Allergic Bronchopulmonary Aspergillosis (ABPA)
• Chronic airway colonization with Burkholderia cepacia (defined as 2 or more prior positive sputum or BAL cultures)
• Pregnancy
• Chronic oral corticosteroid use
• Febrile illness within two weeks of Visit 1
• Unable to provide consent (patients under age of 18 will require both parental consent AND patient assent)
• Current cigarette smoking, cessation of smoking within 6 weeks of Visit 1, or more than 10 pack-years of prior smoking

Where it is running

• The Ohio State University — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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