Treatment of Bronchial Asthma With Borage and Echium Seed Oils
Completed · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Bronchial Asthma
In brief
The aim of this trial is to determine the efficacy of a combination of two botanicals oils, borage seed oil and echium seed oil, as a potential treatment for bronchial asthma.
Key facts
- Study ID
- NCT00806442
- Run by
- Brigham and Women's Hospital
- People needed
- 43
- Starts
- 2008-12-01
- Expected to finish
- 2012-08-01
- Last updated by the study team
- 2017-07-03
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of bronchial asthma
- Male or female 18 years to 65 years of age
- FEV1 50 to 90% of predicted, or personal best.
- Improvement of >=12% FEV1 with bronchodilator
You may not qualify if…
- Pregnant or nursing
- Smoking history of > 10 pack years or active smoking within the past year.
- Due to possible effects on leukotriene biosynthesis, use of the following asthma treatments within the preceding month will be exclusion criteria:
- leukotriene modifying drugs,
- theophylline
- oral steroids.
- dietary supplements with fatty acids or other products that may interfere with leukotriene generation.
- Treatment within the previous three months with omalizumab (monoclonal antibody directed against IgE)
- Subjects will not be permitted to take non-steroidal anti-inflammatory drugs in the week prior to any measurements of ex vivo leukotriene generation because of their effects on leukotriene biosynthesis via inhibition of prostaglandin generation.
- A history of aspirin-sensitive asthma
- Significant abnormalities in CBC, differential white cell count, renal function, and liver function, or urinalysis.
- Any serious co-morbid medical condition.
Where it is running
- Asthma Research Center, Brigham and Women's Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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