Mayo Acute Stroke Trial for Enhancing Recovery

Completed · Phase 2

Conditions studied: Ischemic Stroke

In brief

This study involves treating patients that have suffered an acute ischemic stroke with the medication donepezil (Aricept ®). The hypothesis is that taking donepezil (FDA-approved for the treatment of Alzheimer's Disease) for the first 90 days following a stroke enhances recovery.

Key facts

Study ID

NCT00805792

Run by

Mayo Clinic

People needed

33

Starts

2008-11-01

Expected to finish

2010-09-01

Last updated by the study team

2021-07-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Definite or probable acute ischemic cerebrovascular syndrome (AICS), as defined by Kidwell et al (Stroke. 2003;34:2995-8).
• Experimental treatment started within 24 hours of onset of symptoms.
• Age ≥ 18 years.
• Ability and willingness to return for follow-up visits.
• Willingness of an available informant who knows the patient well to participate in informant-based questionnaires for the duration of the follow-up period.
• Living in independent or semi-independent living situation before the stroke.
• Fluent in English before the stroke.
• Provides written informed consent.
• Near visual acuity of at least 20/200 in at least one eye.
• Auditory acuity of at least having the ability to detect finger rubbing in at least one ear.

You may not qualify if…

• Parkinson's disease or restless leg syndrome.
• Partial or generalized seizures.
• No acute decompensated heart failure
• Routinely requiring daytime supplemental oxygen before the stroke; study participants on continuous positive air pressure (CPAP) for obstructive sleep apnea remain eligible.
• Gastrointestinal or genitourinary surgery within 1 month of screening.
• Gastrointestinal bleeding.
• Syncope or symptomatic bradycardia.
• Creatinine ≥ 3.5 mg/dL or requiring dialysis.
• Peptic ulcer disease.
• Asthma.
• Tracheostomy or endotracheal intubation.
• Taking donepezil or other acetylcholinesterase inhibitor at screening.

Where it is running

• Mayo Clinic — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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