Screening for Latent Tuberculosis Infection (LTBI) in US Army Recruits

Completed · Not applicable

Conditions studied: Latent Tuberculosis Infection

In brief

The overall objective of this study is to assess the feasibility and potential impact of using a targeted testing approach and 2 interferon-gamma release assays (IGRA) to screen for latent tuberculosis (TB) infection (LTBI) among military recruits. The current policy of universal application of the Mantoux tuberculin skin test (TST) to screen for LTBI may result in many TST reactions among recruits who are at low risk for LTBI. The central hypothesis is that targeted testing by use of the questionnaire will reduce unnecessary testing of low-risk recruits without affecting the identification of higher-risk recruits. The secondary hypothesis is that many discordant results between the TST and IGRA may be explained by cross-reactivity to non-tuberculous mycobacteria (NTM) with the TST.

Key facts

Study ID

NCT00804713

Run by

Henry M. Jackson Foundation for the Advancement of Military Medicine

People needed

2017

Starts

2009-03-01

Expected to finish

2022-08-01

Last updated by the study team

2023-03-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Any recruit, age 18 years or older, undergoing routine entry-level medical processing at Fort Jackson

You may not qualify if…

• If they have history of severe reactions to TST (e.g., blistering, scar, or symptoms of immediate hypersensitivity)
• If they are unwilling to provide written consent for the study
• If they are unwilling to provide Health Insurance Portability and Accountability Act (HIPAA) authorization

Where it is running

• Fort Jackson, SC — Columbia, South Carolina, United States

Full record on ClinicalTrials.gov

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