Treatment of Sleep Disordered Breathing In Acute Decompensated Heart Failure Patients

Completed · Phase 4

Conditions studied: Heart Failure, Sleep Apnea Syndromes

In brief

Heart Failure affects 5-6 million Americans and there are about 550 thousand new cases of heart failure every year. There are approximately 3 million hospital admission for acute decompensated heart failure with hospital readmission rate of 20% at 30 days and 50% at 60 day, costing up to 20 billion dollars per year. In our previous study we have discovered that sleep disordered breathing is prevalent in 70% of patients with acute decompensated heart failure. We hypothesize that, detection and treatment of sleep disordered breathing in acute decompensated heart failure patients will reduce episodic hypoxic events during acute decompensation and may decrease hospital length of stay and reduce future readmissions.

Key facts

Study ID

NCT00804349

Run by

Albert Einstein Healthcare Network

People needed

6

Starts

2008-10-01

Expected to finish

2011-10-01

Last updated by the study team

2020-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients over the age of 18 and able to consent
• NYHA Class III/IV Symptoms
• Objective Evidence of Heart Failure
• Physical Exam consistent with Heart Failure
• BNP greater than 500
• Radiographic Evidence of Heart Failure
• SDB (AHI > 5/hour) on Nexan CPS
• Ability to tolerate appropriate medical therapy for Heart Failure
• Willingness to follow-up as an outpatient after discharge

You may not qualify if…

• Patients with known Sleep-Disordered Breathing currently using CPAP or BiPAP
• Patients with known COPD
• Patients with known restrictive lung disease
• Patients with tracheostomy in place
• Acute MI/Acute Coronary Syndrome at time of hospitalization
• Cardiogenic Shock
• Troponin Leak greater than 0.08
• Patients with major multisystem disorders
• Expected survival less than 6 months
• End Stage Renal Disease on Dialysis
• Chronic Liver Disease
• Albumin level less than 3.
• Patients from Nursing homes

Where it is running

• Albert Einstein Medical Center — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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