Oral 6R-BH4 for the Treatment of Isolated Systolic Hypertension and Endothelial Dysfunction

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Isolated Systolic Hypertension, Endothelial Dysfunction

In brief

This study is designed to assess the safety and efficacy of twice-daily oral dosing of 6R-BH4 to improve endothelial function, reduce systolic blood pressure and reduce arterial stiffness.

Key facts

Study ID

NCT00802893

Run by

Johns Hopkins University

People needed

3

Starts

2008-12-01

Expected to finish

2009-05-01

Last updated by the study team

2017-08-21

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• No change in prescribed antihypertension medications within the previous 30 days
• Study staff able to visualize and measure the brachial artery diameter by high resolution vascular ultrasound required for FMD measurements
• ISH with the following mean seated BP: SBP > 145 and < 180 mmHg. Diastolic blood pressure < 90mmHg

You may not qualify if…

• Has known hypersensitivity to 6RBH4 or its excipients
• Pregnant or breastfeeding at screening
• Use of any investigational product or investigational medical device within 30 days prior to screening
• Current disease or condition that would interfere with study participation or safety such as the following: heart failure, atrial fibrillation, aortic valve disease, bleeding disorders, history of repeated syncope or vertigo, severe GERD, GI ulcer, symptomatic coronary or peripheral vascular disease, arrhythmia, serious neurologic disorders including seizures, organ transplant or organ failure
• Hypertension secondary to other medical conditions
• Any severe comorbid condition that would limit life expectancy to <6 months
• Current use of any nicotine containing substances
• History of drug or alcohol abuse
• MI, stroke or surgery within 90 days before Screening Visit
• CABG within 6 months before the Screening Visit
• Serum creatinine >2.0mg/dl or AST, ALT, GGT levels >2times upper limit of normal
• Concomitant treatment with: any drug known to inhibit folate metabolism, any phosphodiesterase-5 or -3 inhibitor
• Previous treatment with any formulation of BH4

Where it is running

• Johns Hopkins University — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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