Dopamine and Insulin Resistance

Completed · Not applicable

Conditions studied: Obesity

In brief

Obese individuals have fewer striatal dopamine type 2 receptors (DRD2) than normal weight individuals. Lower DRD2 levels are associated with addiction and a decreased sense of pleasure.Obesity is also associated with insulin resistance (poor insulin action).We propose that insulin resistance and low DRD2 are associated. Using PET imaging,we aim to determine DRD2 binding potential (BP) in the brain is associated with insulin resistance and neuroendocrine hormone levels. Obese participants will be compared to lean, gender and age similar participants. We also aim to determine the effect of caloric restriction on DRD2 BP in obese subjects

Key facts

Study ID

NCT00802204

Run by

Vanderbilt University

People needed

28

Starts

2008-12-01

Expected to finish

2012-12-01

Last updated by the study team

2017-05-10

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 18-60 yrs
• obese BMI > 30kg/m2 and Weight less than 350 lbs
• lean control BMI 18-25kg/m2

You may not qualify if…

• Structured exercise > equivalent to 30mins 5x week of walking times a week
• History of Substance Abuse, including but exclusive to alcohol, cocaine, marijuana, heroin, nicotine
• Current psychiatric disorder or significant h/o disorder
• Use or any antidepressants or antipsychotics for last 3-6months or depot antipsychotics in the last 12 months
• Any condition felt by PI or co-investigators to interfere with ability to complete the study
• Inability to abstain from alcohol, physical exercise or > 1 cup of coffee or equivalent daily for 3 days prior to imaging studies
• Significant co-morbidities including atherosclerotic disease, metabolic disease, liver or renal insufficiency or abnormality found on MRI
• Any condition which would interfere with MRI or PET studies, e.g. claustrophobia, cochlear implant, metal fragments in eyes, cardiac pacemaker, neural stimulator, tattoos with iron pigment and metallic body inclusions or other metal implanted in the body which may interfere with MRI scanning
• Subjects on medications determined by PI, ex. sibutramine, frequent benzodiazepines or related drugs, which could affect quality of study for last 3 months.

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.