Combined Kidney and Bone Marrow Transplantation to Prevent Kidney Transplant Rejection

Completed · Phase 2

Conditions studied: Kidney Transplantation, Kidney Failure, Chronic

In brief

In small initial studies, combined kidney and bone marrow transplants from the same donor have permitted some individuals to stop taking anti-rejection medicines without rejecting their transplant. This clinical trial will study this method in a greater number of people to determine if it is indeed effective and safe.

Key facts

Study ID

NCT00801632

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

5

Starts

2008-12-01

Expected to finish

2014-11-01

Last updated by the study team

2015-11-10

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Awaiting first or second transplant with a living donor or first transplant with a cadaveric donor
• For living-donor transplants, must have one or more HLA antigen-mismatched donors identified
• Serologic evidence of prior exposure to Epstein-Barr virus (EBV)

You may not qualify if…

• ABO blood group-incompatibility for a kidney graft of tissue from a donor
• Decreased circulating white blood cell count
• Positive for HIV-1, hepatitis B and C viruses
• Have had prior radiation therapy that could limit dose
• Lung capacity <50% of predicted normal
• Evidence of insufficient cardiac capacity
• Unwilling to use adequate contraception until 2 years after transplant
• Lactation or pregnancy
• Presence of antibody against the donor

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.