Study of Endothelial Keratoplasty Outcomes

Completed · Not applicable

Conditions studied: Fuchs' Endothelial Corneal Dystrophy, Bullous Keratopathy, Iridocorneal Endothelial Syndrome, Posterior Polymorphous Dystrophy

In brief

Endothelial keratoplasty is a cornea-sparing transplant technique that replaces only the diseased endothelial cell layer of the patient's cornea. This technique offers many advantages compared with traditional full-thickness cornea transplants. Patients experience minimal change in glasses prescription and usually recover useful vision within weeks. Visual fluctuations are minimal during the healing process. The patient's cornea remains structurally intact and is more resistant to injury. Endothelial keratoplasty is undergoing rapid and widespread adoption. Between 2005 and 2007, the number of corneas placed by US eye banks for endothelial keratoplasty increased ten-fold (2007 Eye Bank Association of America Annual Report). However, the procedure is less than 10 years old, and little is known about long term outcomes. Endothelial keratoplasty candidates at our center are invited to participate in an open enrollment, prospective study of the long-term outcomes of this procedure.

Key facts

Study ID

NCT00800111

Run by

Cornea Research Foundation of America

People needed

2593

Starts

2008-02-01

Expected to finish

2018-02-01

Last updated by the study team

2019-01-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female aged 18 or older
• Scheduled to undergo endothelial keratoplasty
• Able to provide written informed consent.

You may not qualify if…

• Age less than 18 years

Where it is running

• Price Vision Group — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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