Enteral Naloxone Versus a Traditional Bowel Regimen for the Prevention of Opioid Induced Constipation in Trauma Patients

Stopped early · Phase 4

Conditions studied: Constipation, Analgesia

In brief

The purpose of this study is to determine if enteral naloxone is more effective than a traditional bowel regimen in the prevention and treatment of constipation and impaired gastric motility in critically ill trauma patients.

Key facts

Study ID

NCT00799201

Run by

CAMC Health System

People needed

3

Starts

2007-08-01

Expected to finish

2012-10-01

Last updated by the study team

2015-07-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and non-pregnant females > 18 years of age and < 65 years of age
• MSICU admission to the trauma service at the General Hospital
• Scheduled for continuous infusion/administration of opiate analgesics for at least 24 hours
• Access for enteral administration of medications and tube feeds
• Initiation of tube feeds

You may not qualify if…

• NPO
• Pregnancy
• < 18 years of age or > 65 years of age
• Pancreatitis
• Ileus
• Large bowel obstruction present on plain X-ray or CT scan
• Recent intestinal anastomosis (within 2 weeks)
• Section of large bowel removed (within 2 weeks)
• Contraindications to metaclopramide (Reglan) such as parkinson's disease, tardive dyskinesia, etc.
• Traumatic brain injury with a glasgow coma score of at least 8
• Use of pharmacologic paralytics or neuromuscular blockade (NMB)
• Non-english speaking patients

Where it is running

• Charleston Area Medical Center, General Hospital — Charleston, West Virginia, United States

Full record on ClinicalTrials.gov

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