How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?

Completed · Phase 4

Conditions studied: Glaucoma

In brief

To determine whether one glaucoma eye drop is less likely to cause changes to the surface of the eye (conjunctiva) than another. The two different prostaglandins are Xalatan and Travatan Z.

Key facts

Study ID

NCT00798694

Run by

Wills Eye

People needed

58

Starts

2008-11-01

Expected to finish

2011-02-01

Last updated by the study team

2018-07-12

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 21 or older
• Able to understand protocol and agree to 3 visits
• Any type of glaucoma
• Selective laser trabeculoplasty, Argon laser trabeculoplasty, peripheral iridotomy accepted
• Naïve: No prior glaucoma treatment (medical or surgical)
• If patient non-compliant, must be off meds 3 months
• Xalatan: At least one month use

You may not qualify if…

• Both Groups: Any history of ocular surface disease
• Dry eye syndrome or prior Restasis use
• Prior ocular surgery other than cataract extractions
• Uveitis or other inflammatory disease of the eye or adnexa
• Systemic medications that might influence ocular inflammation
• Any active inflammation or infection
• Pregnancy or intention to become pregnant
• Naïve: Prior use of topical glaucoma medication unless off for 3 months.
• Use of preserved artificial tear preparations in last 30 days and more than one year history of chronic use
• Xalatan: Prior use of Travatan or Travatan Z

Where it is running

• Wills Eye Glaucoma Service — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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