Outcomes of Mechanically Ventilated Patients With Low Serum Testosterone
Completed
Conditions studied: Acute Respiratory Failure
In brief
This is a study to determine the testosterone serum levels in male patient with acute respiratory failure requiring mechanical ventilation. The objective is to determine if low levels exist in this population and if it correlates with length of mechanical ventilation. Hypothesis: Serum testosterone levels in mechanically ventilated male patients are significantly decreased from normal levels and correlate with disease severity and outcomes.
Key facts
- Study ID
- NCT00797433
- Run by
- The University of Texas Health Science Center, Houston
- People needed
- 28
- Starts
- 2008-12-01
- Expected to finish
- 2010-08-01
- Last updated by the study team
- 2010-09-21
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Male
- Age > 18
- Admission diagnosis of acute respiratory failure requiring endotracheal intubation and mechanical ventilation for > 24 hours
- APACHE II score > 15 (APACHE: Acute Physiology and Chronic Health Evaluation - general indicator of disease severity and outcomes predictor)
You may not qualify if…
- Chronic mechanical ventilation (i.e. patients on mechanical ventilatory support for > 21 days for at least 6 hours per day)
- Patients on mechanical ventilation for > 48 hours prior to MICU admission
- Non-invasive mechanical ventilation
- Patients intubated and mechanically ventilated for drug overdose and anticipated to be intubated for < 24 hours
- Known diagnosis of hypogonadism (requiring testosterone hormonal supplementation) or currently receiving testosterone therapy or received testosterone therapy within 30 days of MICU admission
- History of testicular, prostate or pituitary tumor
- Chronic use of systemic steroids prior to admission
- Terminally ill patients who are not expected to live longer that 3 months
Where it is running
- University of Texas Health Science Center at Houston — Houston, Texas, United States
Full record on ClinicalTrials.gov
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