Heart Rate Variability in Trauma Patients

Completed

Conditions studied: Trauma

In brief

The purpose of this study is to develop new triage tool for trauma patients based on HRV. EKG will be prospectively measured in trauma patients in two locations: in the prehospital setting (the field and during transport by helicopter) and in the hospital setting. In each case HRV will be derived from the EKG signal, will be correlated with other non-invasive signals (e.g. near infrared spectroscopy (NIR), and bispectral EEG (BIS)), along with other routinely measured variables (blood pressure, respiratory rate, pulse oximetry, etc), will be correlated with injury severity and day of discharge. An algorithm will be constructed using multiple linear regression. The hypotheses are: 1. reduced HRV in the field correlates with bad outcome; 2. the specificity and efficiency of HRV as a screening tool can be improved by controlling factors such as heart rate, age, gender, respiratory rate, and pulse oxygen saturation; 3. an easy to interpret HRV index can be derived that can be used for trauma triage or diagnosis.

Key facts

Study ID

NCT00795535

Run by

University of Miami

People needed

95

Starts

2007-05-01

Expected to finish

2014-12-01

Last updated by the study team

2015-02-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who meet level 1 trauma criteria and are transported by helicopter to Ryder Trauma Center
• An additional study population will be comprised of patients already admitted to the trauma center for presumptive Traumtaic Brain Injury

You may not qualify if…

• None

Where it is running

• Ryder Trauma Center — Miami, Florida, United States

Full record on ClinicalTrials.gov

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