Partnership for Rapid Elimination of Trachoma
Completed · Phase 4
Conditions studied: Trachoma
In brief
Trachoma, an ocular infection caused by C. trachomatis, is the second leading infectious cause of blindness worldwide. Years of repeated infection with C. trachomatis cause the eyelid to scar and contract and ultimately to rotate inward such that the eyelashes rub against the eyeball and abrade the cornea (trichiasis). The World Health Organization (WHO) has endorsed a multi-faceted strategy to combat trachoma, which includes the use of antibiotic treatment to reduce the community pool of infection with C. trachomatis. The objective of this study is to conduct a randomized, community-based trial in three countries (Niger, Tanzania and The Gambia), representing different baseline endemicities, of alternative coverages and frequencies of administration of mass antibiotic treatment as well as to determine the cost-effectiveness of these different strategies from a program perspective.
Key facts
- Study ID
- NCT00792922
- Run by
- Johns Hopkins University
- People needed
- 128
- Starts
- 2008-05-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2017-07-18
Who can join
Age: any, up to 5. Sex: any. Healthy volunteers: accepted.
Where it is running
- UCSF Proctor Foundation — San Francisco, California, United States
- Johns Hopkins University — Baltimore, Maryland, United States
- London School of Hygiene and Tropical Medicine — London, United Kingdom
Full record on ClinicalTrials.gov
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