Physiologic Monitoring of Antidepressant Response
Completed · Phase 4 · Has a placebo group
Conditions studied: Major Depression
In brief
Primary: to identify physiologic indicators of venlafaxine treatment response using quantitative EEG (QEEG) cordance, and to determine if cordance changes are specifically associated with response to venlafaxine; Secondary: to determine if cordance changes early in the course (i.e., prior to improvement in clinical symptoms) of venlafaxine (or another antidepressant if venlafaxine is not clinically indicated for a particular patient) are predictive of later clinical response.
Key facts
- Study ID
- NCT00792168
- Run by
- University of California, Los Angeles
- People needed
- 38
- Starts
- 1996-11-01
- Expected to finish
- 1998-12-01
- Last updated by the study team
- 2025-12-22
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All subjects will meet DSM-IV criteria for depression on the basis of a SCID-P interview, with subjects in the placebo controlled phase of the study having a score on the 17-item Ham-D > 18 (with item #1 > 2). Subjects will meet criteria both at recruitment, and after a one-week single blind placebo wash-in. - Study includes outpatients only.
You may not qualify if…
- All subjects will have no serious medical illness.
- The investigators will exclude patients also meeting criteria for the following groups of axis I diagnoses:
- delirium or dementia
- substance-related disorders
- schizophrenia or other psychotic disorders
- eating disorders.
- In addition, patients meeting criteria for cluster A or B axis II diagnoses will be excluded.
- Subjects with a history of current or past active suicidal ideation, or suicide attempts will be excluded from the placebo-controlled phase of the study.
Where it is running
- University of California — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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