Determination of Absorption and Elimination of Lamotrigine-XR

Completed · Phase 1/Phase 2

Conditions studied: Epilepsy, Seizures, Bipolar Disorder, Bipolar Depression

In brief

People over 65 years of ag break down (metabolize) drugs differently than younger adults. It is not known why this happens or how elderly people absorb or break down these drug differently. These difference may show that elderly individuals need lower doses of medications to avoid possible toxicity. We are interested in studying how yor body absorbs and breaks down your lamotrigine medication. This research may indicate that doses of lamotrigine should be lowered as people get older.

Key facts

Study ID

NCT00789113

Run by

University of Minnesota

People needed

12

Starts

2008-11-01

Expected to finish

2011-01-01

Last updated by the study team

2016-01-20

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical Diagnosis of Epilepsy or Bipolar Depression
• able to have a venus catheter implanted for blood withdrawal and for intravenous infusion
• equal to or over the age of 65

You may not qualify if…

• not on any medication that will interact with lamotrigine e.g. carbamazepine, phenytoin, phenobarbital, valproic acid, St. John's wort, rifampin, tamoxifen

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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