Impact of Maternal Pomegranate Juice on Brain Injury in Infants With Intrauterine Growth Restriction (IUGR)

Completed · Not applicable · Has a placebo group

Conditions studied: Intrauterine Growth Restriction

In brief

Infants with intrauterine growth restriction are known to be at increased risk for long term neurodevelopmental delay into adulthood. The main mechanism for this is likely decreased blood flow to the brain secondary to altered placental blood flow. Antioxidants may serve to protect the developing brain from this process. Animal studies have shown that pomegranate juice protects the fetal brain from injury in a model of stroke. This clinical trial is intended to evaluate if giving mothers pomegranate juice during the last several weeks of pregnancy can help protect intrauterine growth restricted babies' brains.

Key facts

Study ID

NCT00788866

Run by

Washington University School of Medicine

People needed

80

Starts

2008-12-01

Expected to finish

2014-10-01

Last updated by the study team

2014-10-17

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Healthy expecting mothers two weeks from their expected due dates
• No evidence of IUGR
• No evidence of fetal problems
• Phase II:
• Inclusion Criteria:
• Expecting mother with a fetal diagnosis of intrauterine growth restriction (IUGR) defined by estimated fetal weight <10th percentile for gestational age
• 24 - 34 weeks gestation

You may not qualify if…

• Major congenital abnormalities
• Known fetal chromosomal disorder
• Maternal illicit drug use
• Maternal IV and Hepatitis C infection
• Premature rupture of membranes

Where it is running

• St Louis Children's Hospital — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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