Use of Nitric Oxide Metabolites for Predicting Embryo Quality in In-Vitro Fertilization (IVF)

Stopped early · Not applicable

Conditions studied: Infertility

In brief

Improvements in In-Vitro Fertilization (IVF) outcomes have largely been due to the generation of excess embryos allowing for multiple embryo transfer. Unfortunately this has also increased the risk of multiple pregnancy with associated maternal and neonatal morbidity and mortality. The investigators believe that the concentration of nitric oxide metabolites measured in the culture medium from the first day of culture can identify the best quality embryos allowing us to transfer a limited number of embryos without compromising the optimum chance for pregnancy.

Key facts

Study ID

NCT00788619

Run by

Johns Hopkins University

People needed

2

Starts

2009-01-01

Expected to finish

2009-10-01

Last updated by the study team

2017-12-11

Who can join

Age: 21 and older, up to 37. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age 21-37
• Female
• Less than two previous unsuccessful IVF cycles

You may not qualify if…

• Day 3 FSH >9.9
• Fewer than 8 mature oocytes retrieved
• Fewer than 8 normally fertilized embryos on day 2 after fertilization

Where it is running

• Johns Hopkins Fertility Center — Lutherville, Maryland, United States

Full record on ClinicalTrials.gov

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