Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly

Completed · Not applicable

Conditions studied: Lumbar Spondylosis, Cervical Spondylosis, Hip Osteoarthritis, Knee Osteoarthritis

In brief

The purpose of this research is to determine if post-operative cognition will be better if the general anesthesia for surgery is done with an inhaled (gas through a breathing tube) or intravenous (medicine injected in the IV) general anesthetic technique.

Key facts

Study ID

NCT00788008

Run by

Duke University

People needed

200

Starts

2008-11-01

Expected to finish

2013-12-01

Last updated by the study team

2015-03-26

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients (aged 65 years or older) scheduled for elective spine or major joint replacement (total hip or total knee arthroplasty) at Duke University Medical Center or the Durham VA Medical Center

You may not qualify if…

• not fluent in English and able to comprehend the English language
• have severe visual or auditory handicaps
• Carry a diagnosis of dementia or score < 18 on the Mini-Mental State Examination (MMSE) as calculated from the Modified Mini-Mental State (3MS) (see D4 below)
• have allergies to eggs, propofol, isoflurane, fentanyl, remifentanil, or pregabalin

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States
• VAMC — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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