Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)

Completed

Conditions studied: Sick Sinus Syndrome

In brief

A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead. When RV pacing is discontinued, the altered repolarization persists for several weeks. This phenomena is traditionally described as "T-wave memory" based upon the 12-lead ECG appearance of inverted T-Waves. The investigators are using the ECGI technique to produce three dimensional electroanatomical images of this phenomena in patients with dual chamber pacemakers. Echocardiography will also be used to image the mechanical effects of RV pacing and T-wave memory. The images will show the spatial distribution of altered repolarization and allow us to correlate any mechanical consequences of this phenomena that may exist.

Key facts

Study ID

NCT00785564

Run by

Washington University School of Medicine

People needed

13

Starts

2007-11-01

Expected to finish

2011-09-01

Last updated by the study team

2019-01-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Implanted dual chamber pacemaker for sick sinus syndrome with no history of complete heart block.

You may not qualify if…

• Persistent atrial fibrillation that is not suppressed by medications.

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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