Aspirin and Antiretroviral Therapy in HIV Infected Patients

Stopped early · Phase 2 · Has a placebo group

Conditions studied: HIV Infection

In brief

The purpose of this study is to examine the effects of HIV treatment (antiretroviral therapy) and aspirin use on risk for cardiovascular disease among HIV infected persons.

Key facts

Study ID

NCT00783614

Run by

Hennepin Healthcare Research Institute

People needed

22

Starts

2008-10-01

Expected to finish

2010-06-01

Last updated by the study team

2017-11-21

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• HIV-infected (by positive HIV Ab or detectable HIV RNA level)
• No ART for at least previous 3 months
• Ready to start or re-start ART (regimen pre-chosen by patient and provider)

You may not qualify if…

• Age < 18 years, or >60 years
• Pregnancy
• Current aspirin use
• Presence of known atherosclerotic CVD determined by:
• Previous myocardial infarction
• Significant coronary atherosclerosis by angiography
• Coronary revascularization procedure (coronary stent or surgical bypass)
• Previous cerebral vascular accident (stroke)
• Ischemic cardiomyopathy
• Carotid stenosis (>25% narrowing by carotid ultrasound)
• Aortic aneurysm
• Symptomatic peripheral vascular disease (claudication)
• Surgical revascularization procedure of peripheral vessels
• Hospitalization (within prior 2 weeks of study entry)
• Concurrent self-limited bacterial infections (does not include chronic viral infections)
• Clinical or pathologic diagnosis of systemic vasculitis
• Active drug or alcohol use

Where it is running

• Hennepin County Medical Center — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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