Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality
Completed · Phase 2 · Has a placebo group
Conditions studied: Chronic Pancreatitis, Insulin Resistance, Normal or Mildly Abnormal Stool Fat Levels
In brief
The purpose of this study is to determine if study drug (Pioglitazone) treatment will improve pre-diabetes (insulin resistance) or ealy diabetes and improve clinical symptoms (pain) or laboratory evidence of chronic pancreatitis. The goal of the investigators is to gather information from this study to help gain understanding of a potential therapy for chronic pancreatitis.
Key facts
- Study ID
- NCT00782795
- Run by
- University of Michigan
- People needed
- 64
- Starts
- 2008-11-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2018-01-11
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Insulin resistance or mild diabetes mellitus
- Symptoms of abdominal pain
- Xray test showing damage to the pancreas
- Normal or mildly abnormal stool fat levels
You may not qualify if…
- Mentally disabled patients
- Women who are planning pregnancy, pregnant or lactating/nursing
- Chronic pancreatitis is due to other specific conditions
- Autosomal dominant pancreatitis
- Classic cystic fibrosis with lung involvement
- Autoimmune pancreatitis
- Pancreatic cancer
- Biliary obstruction (non-pancreatic cause)
- Abdominal trauma
- Hypercalcemia
- Hypertriglyceridemia
- Surgical resection of the head of the pancreas
- Alcohol consumption within prior 2 months
- Specific medical conditions
- Gastric surgery
- Celiac sprue
- Crohns disease
- Heart failure
- Kidney failure
- Cirrhosis or liver disease
- Osteoporosis
- Blood clotting disorder
- Visual problems
- Low albumin
- Low BMI
Where it is running
- University of Michigan Health System — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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