AZD6765 Severe Major Depressive Disorder (MDD) IV

Completed · Phase 2 · Has a placebo group

Conditions studied: Major Depressive Disorder

In brief

The purpose of this research study is to determine whether AZD6765 has an effect on the patient's depression when taken together with current depression medication. In addition, information will be gathered on how well AZD6765 is tolerated, investigate the levels of AZD6765 and the levels of the current depression medication in the blood. In addition, the research staff will determine if AZD6765 has any mood or calming effects (how you feel).

Key facts

Study ID

NCT00781742

Run by

AstraZeneca

People needed

152

Starts

2008-10-01

Expected to finish

2010-03-01

Last updated by the study team

2012-07-25

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed informed consent before any study-related procedures start.
• The patient is previously diagnosed with Major Depressive Disorder (MDD) and currently taking an antidepressant for at least 6 weeks.
• Patient has a history of poor response to 1 or more antidepressants (in addition to the antidepressant the patient is taking at enrollment) after exposure at adequate doses or maximum tolerated doses for ≥4 weeks.

You may not qualify if…

• Patient has a lifetime history of schizophrenia, bipolar, psychosis or psychotic depression.
• Patient has a lifetime history of failure to ECT therapy.
• Patient is pregnant or breast feeding.
• Length of current episode of depression exceeds ≥2 years.

Where it is running

• Research Site — Little Rock, Arkansas, United States
• Research Site — Los Angeles, California, United States
• Research Site — Orange, California, United States
• Research Site — San Diego, California, United States
• Research Site — Santa Ana, California, United States
• Research Site — Hartford, Connecticut, United States
• Research Site — New Haven, Connecticut, United States
• Research Site — Boca Raton, Florida, United States
• Research Site — Gainsville, Florida, United States
• Research Site — Hollywood, Florida, United States
• Research Site — Jacksonville, Florida, United States
• Research Site — Atlanta, Georgia, United States
• Research Site — Roswell, Georgia, United States
• Research Site — Hoffman Estates, Illinois, United States
• Research Site — Joliet, Illinois, United States
• Research Site — Overland Park, Kansas, United States
• Research Site — Lake Charles, Louisiana, United States
• Research Site — Shreveport, Louisiana, United States
• Research Site — Haverhill, Massachusetts, United States
• Research Site — St Louis, Missouri, United States
• Research Site — Willingboro, New Jersey, United States
• Research Site — Albuquerque, New Mexico, United States
• Research Site — Rochester, New York, United States
• Research Site — East Stroudsburg, Pennsylvania, United States
• Research Site — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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