Uncomplicated Nausea and Vomiting in the Emergency Department

Completed · Phase 4

Conditions studied: Nausea, Vomiting

In brief

Nausea and vomiting is a common complaint in the emergency department. Treatment is important for many reasons. In addition to patient comfort, there are adverse effects secondary to vomiting such as dehydration, metabolic alkalosis, Mallory-Weiss tears, and aspiration. Two mediations common used for nausea in ED patients include Ondanesetron and Metoclopramide.

Key facts

Study ID

NCT00778011

Run by

WellSpan Health

People needed

137

Starts

2005-11-01

Expected to finish

2006-12-01

Last updated by the study team

2012-06-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older with nausea and at least 1 episode vomiting in the last 12 hours presenting to the York Hospital Emergency Department

You may not qualify if…

• Patients known to have hypersensitivity to the drugs ondansetron or metoclopramide
• gastrointestinal hemorrhage, mechanical obstruction or perforation
• patients with pheochromocytoma
• seizure disorder
• patients receiving other drugs which are likely to cause extrapyramidal reactions such as butapherones and phenothiazines
• patients experiencing hyperemesis gravidum
• patients unable to understand the informed consent (intoxicated, Spanish speaking)
• prior antiemetics within 12 hours
• inability to perform visual analog scale
• renal dialysis

Where it is running

• York Hospital — York, Pennsylvania, United States

Full record on ClinicalTrials.gov

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