Energy Metabolism and Cognitive Aging

Completed · Not applicable

Conditions studied: Mild Cognitive Impairment

In brief

Participants 60 and older with and without Parkinson's disease who have mild cognitive decline will be randomized to either a standard higher carbohydrate diet or a carbohydrate-restricted ketogenic diet for 8 weeks. The main hypothesis is that nutritional ketosis will improve memory functioning. Pre and post-memory testing will be performed. Subjects will also provide blood samples and a subset of subjects with receive magnetic resonance brain imaging.

Key facts

Study ID

NCT00777010

Run by

University of Cincinnati

People needed

62

Starts

2008-09-01

Expected to finish

2017-03-15

Last updated by the study team

2017-03-24

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 60 years or older
• Mild cognitive impairment

You may not qualify if…

• Diabetes
• Medications that have effect on memory
• Memory problems due to medical issues (ie head injury, stroke, untreated sleep apnea etc.)
• Unable to complete an MRI scan

Where it is running

• University of Cincinnati — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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