Autologous Fat Grafting to the Breast

Status unconfirmed · Not applicable

Conditions studied: Micromastia, Breast Ptosis, Implant Failure, Breast Reconstruction, Congenital Malformations

In brief

Structural fat grafting is a form of tissue transfer where the autologous fat is harvested and subsequently transferred to a different region of the body at the same setting. It is an excellent technique for filling soft tissue and contour defects. Fat has the benefit of being abundantly available and easy to harvest. Further more, it is cheap and autogenous and thus lacks the side effects of synthetic fillers or implants. Autogenous fat transfer is a relatively common procedure performed by plastic and reconstructive surgeons. The goal of fat grafting is to provide the patient with a predictable, long lasting autogenous soft tissue augmentation. Autogenous fat transfer has been used extensively as an adjunct to facial rejuvenation. As well it has been applied to body contouring and augmentation of the hips, trochanteric areas, thighs and buttocks, back, torso and breast. The transfer of autologous fat dates back to 1890s and more specifically as injectable grafts since the 1920s. However, over the past 20 years the popularity of structural fat grafting has increased as a contouring modality. Fat transfer to the breast, popularized by Coleman, has been performed internationally since the 1990s. Despite the duration, the literature lacks accurate outcomes data on fat transfer to the breast and questions regarding the viability of adipocytes after the transfer exist. Sources from various publications show cell viability of up to 100% however studies of long term clinical outcomes quote rates of 10% to 80%.

Key facts

Study ID

NCT00775788

Run by

Louisiana State University Health Sciences Center in New Orleans

People needed

50

Starts

2008-06-01

Expected to finish

2010-06-01

Last updated by the study team

2008-11-18

Who can join

Age: 17 and older, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women with the following conditions micromastia, breast ptosis, post mastectomy breast reconstruction, asymmetric breasts, congenital malformations of breast development and for treatment of complications associated with implant augmentation mammoplasty.

You may not qualify if…

• A volunteer who has a positive pregnancy test
• A volunteer who has had a cardiac stent placed within the last two months
• A volunteer with a known, current substance abuse
• A volunteer with a bleeding diathesis
• Untreated breast cancer
• A volunteer who smokes cigarettes
• Medical Conditions including untreated hypertension, renal disease, diabetes mellitus

Where it is running

• Houma Outpatient Surgery Center — Metairie, Louisiana, United States (enrolling)
• Medical Center of Louisiana New Orleans, LSU Health Sciences Center — New Orleans, Louisiana, United States (enrolling)

Full record on ClinicalTrials.gov

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