Hyperglycemia and Oxidative Stress in the Human Brain With Diabetes

Stopped early · Not applicable

Conditions studied: Type 2 Diabetes

In brief

The purpose of this study is to use an MRI exam to measure the concentrations of glutathione (GSH) and Vitamin C (Asc) in the brains of normal healthy persons and type 2 diabetic persons. The study will look at the relationship between chronic hyperglycemia and the levels of these naturally occurring chemicals in the brain.

Key facts

Study ID

NCT00775541

Run by

In-Young Choi, Ph.D.

People needed

5

Starts

2007-10-01

Expected to finish

2009-08-01

Last updated by the study team

2012-06-18

Who can join

Age: 30 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Good health except for having type 2 diabetes
• Being treated with diet, insulin, or oral hyperglycemic agents
• Male or non pregnant female
• Non-smoker
• HbA1c 8 or above
• Able to provide informed consent

You may not qualify if…

• Presence of mental illness
• Co-existing chronic inflammatory condition or neurological disease or diseases associated with abnormal glutathione metabolism
• BMI over 35
• Smoker

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States

Full record on ClinicalTrials.gov

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