Aliskiren and Renin Inhibition in Diastolic Heart Failure
Withdrawn before enrolling · Not applicable
Conditions studied: Diastolic Heart Failure
In brief
This study is being conducted to compare the effects that 2 different combinations of heart failure medications have on the levels of certain blood markers which cause and/or worsen heart failure. Additionally, the investigators will investigate any differences that may exist between Hispanics and Non-Hispanics. The investigators hope to find that Hispanic Americans will have a greater response to this new regimen compared to non-Hispanic Americans.
Key facts
- Study ID
- NCT00773084
- Run by
- Texas Tech University Health Sciences Center
- People needed
- 0
- Starts
- 2008-09-01
- Expected to finish
- 2009-08-01
- Last updated by the study team
- 2015-05-12
Who can join
Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Chronic stable diastolic HF documented by clinical diagnosis and echocardiogram within the last 2 years
- NYHA classes I-III, symptomatically stable (for >1month)
- Age 21-70 years
- Either of Hispanic ethnicity (Mexican American origin) or non-Hispanic white
- Patients on ACE inhibitor therapy (lisinopril)
- Blood pressure >100/75 mmHg
- Adequate birth control
- Patients seen in TTUHSC Cardiology or Internal Medicine clinic for at least two visits since January 2008
You may not qualify if…
- Acute coronary syndrome (within the last month).
- Recent acute diastolic or systolic HF (within the last month)
- Pancreatic disease
- Renal artery stenosis
- Pregnancy
- History of angioedema
- Severe hypotension (systolic BP<90mmHg or mean arterial pressure <65mmHg)
- Hyperkalemia (defined by K+>5 mEq/L)
- Chronic Kidney Disease (Stage 3 and above)
- Systolic dysfunction (ejection fraction below 50%)
- Ethnicity other than Mexican American or non-Hispanic white
Where it is running
- Texas Tech University Health Sciences Center — Lubbock, Texas, United States
Full record on ClinicalTrials.gov
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