Correlation of Calcitonin Gene-Related Peptide (CGRP) Levels in Saliva With the Evolution of an Attack of Migraine

Completed

Conditions studied: Headache, Migraine

In brief

To assess CGRP levels in saliva through the evolution of migraine.

Key facts

Study ID

NCT00772473

Run by

Clinvest

People needed

34

Starts

2008-02-01

Expected to finish

2009-01-01

Last updated by the study team

2009-05-25

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to read, understand, and sign the informed consent
• Subject is between the ages of 18 and 65, either male or female
• Negative pregnancy test for those of childbearing potential.
• Adequate birth control as approved by the investigator if of childbearing potential
• Subjects must fulfill criteria for IHS migraine (1.1 or 1.2) with a history of 1-6 migraines per month within the past 3 months and at least 15 headache free days though out the previous three month time period

You may not qualify if…

• Pregnant or breast feeding
• Presence of any condition or symptoms that would knowingly alter the content of the saliva
• Presence of any medical disease or condition that would interfere with the conduct of the study
• Current use of other medications that would be contraindicated in those patients that will take triptan medications for treatment of migraine symptoms, ie. MAO inhibitors, lithium, methyergonovine, methysergide, or ergotamine-containing products
• Use of migraine preventive medications in the three months prior to screening
• History of drug or alcohol abuse that would interfere with the study
• Any pathology of the salivary glands such as sialadenitis (e.g., Sjorgen's syndrome, viral or bacterial sialadenitis, obstructive sialadentitis)
• History of hypersensitivity or allergy to triptan medications
• Presence of diabetes, salivary gland tumors, liver disease, alcoholism, and neuropathy
• More than 15 days per month of headache within the past 3 months
• Participation in another investigative drug study within the past 30 days

Where it is running

• Clinvest — Springfield, Missouri, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.