The Effects of Omega-3 Fatty Acids on Aspirin Resistance

Completed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Increased Drug Resistance

In brief

The purpose of this study is to determine if omega-3 fatty acids enhance the antiplatelet effects of aspirin.

Key facts

Study ID

NCT00771914

Run by

University of Rochester

People needed

27

Starts

2008-11-01

Expected to finish

2009-01-01

Last updated by the study team

2012-11-06

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Willing to participate by providing informed consent and committing to complete the study. This includes adhering to the study diet.
• No chronic disease by history and based on a complete blood count and comprehensive metabolic profile.
• Commitment to not taking aspirin, non-steroidal anti-inflammatory medications, and to limit fish intake to ≤2 meals during the 7 days prior to each CRC study period. They will also need to abstain from taking a list of over-the-counter medications that include aspirin. For the duration of the study, they will also be asked to abstain from taking fish and flax seed oil supplements.

You may not qualify if…

• Reports the presence of chronic disease (e.g. cardiovascular, renal, hepatic, neurodegenerative, neoplastic, metabolic {diabetes}, hypertension).
• Reports taking a systemic medication chronically.
• History of serious adverse reaction or allergy to aspirin or fish oil.
• Baseline platelet count <100 000 or >500 000, hematocrit <30%, or white blood cell count >20 000.
• Any abnormality from a screening CBC and complete blood count that suggests acute or chronic disease.
• Nicotine user.
• History of alcohol abuse
• Pregnancy by history or urine/serum pregnancy test
• History of intestinal malabsorption syndrome including gastric bypass surgery

Where it is running

• University of Rochester School of Medicine and Dentistry — Rochester, New York, United States

Full record on ClinicalTrials.gov

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